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In PD -synuclein mutations is common and in sporadic PD LBs strongly immunoreactive for wild-type -synuclein with many other protein in their normal or damaged condition (Spillantini et al., 1998)

Interestingly, despite its pronounced effect on lipid accumulation, -viniferin only downregulated the expression of peroxisome proliferator-activated receptor gamma (PPAR), a central transcription factor in adipogenesis, at the highest dose, suggesting that additional mechanisms may contribute to its lipid-lowering effect

A ferroptosis-related gene signature for overall survival prediction and immune infiltration in lung squamous cell carcinoma

The adverse effects derived from this damage and dysfunction are wide-ranging, including hepatotoxicity [8], cellular aging, senescence, genomic instability, inflammation [10], as well as metabolic, neurodegenerative, and cardiac disorders [9, 11] and hereditary diseases that affect the mitochondrial network and cell metabolism [11]