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A 2019 study in the British Journal of Clinical Pharmacology found that a single 800 mg EGCG dose decreased midazolam (a CYP3A4 probe) AUC by approximately 18% in healthy volunteers, suggesting meaningful CYP3A4 modulation [9]

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In contrast, iron chelators (e.g., DFO) exert antimalarial effects by disrupting iron utilization

In turn, we can relate the scope of these dual metabolisms and their modern physiologies to their ancestors impacts on ecology and geochemistry as Earth slowly and discontinuously became oxygenated