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In animal models, this combination has been used to study damage amelioration in multiple sclerosis, peripheral axonal pathology, and brain ischemia

Consistent with the results from germline XKR8 KO mice challenged with LPS, neutrophil-specific XKR8 KO mice displayed significantly reduced NET formation in the lungs, lower levels of extracellular dsDNA in BALF and mitigated lung injury, despite similar levels of neutrophil infiltration following LPS challenge (Fig