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Red pipestone Catlinite is an iron-rich, reddish, soft argillite or claystone typically excavated from beds occurring between hard Sioux Quartzite layers [20] below groundwater level, as the stone erodes rapidly when exposed to the weather and outside air

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The researchers identified these so-called epigenetic changes by using single nuclear ATAC sequencing (snATAC-seq) and single nuclear RNA-sequencing (snRNA-seq) to study RPE cells from young and aged mice three, six and 10 days post-cigarette smoke condensate (CSC) injection, and those exposed to cigarette smoke daily for four months

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