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According to the NIH criteria, a PCOS diagnosis necessitates the presence of both chronic anovulation and clinical or biochemical evidence of hyperandrogenism, after excluding other underlying causes

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These diverse and interconnected functions underscore the critical importance of mitochondria in maintaining cellular health and homeostasis, and perturbations in these processes have been linked to a wide range of diseases, including cardiovascular disorders and cognitive impairments, highlighting the need for further research into mitochondrial function and dysfunction

XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease