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Endothelial cu uptake transporter CTR1 senses disturbed flow to promote atherosclerosis through cuproptosis

Thats the compensation: an alternate drain the cell can open to offset what you did by inhibiting NNMT, which is part of why nonstop inhibition doesnt necessarily keep delivering the same clean effect forever

Also, curcumin, selenium, vitamins C and E are cofactors that promote glutathione absorption and consumption. But as is often the case, stressed-out modern life can translate to a sub-optimal nutrient intake