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Standardisation of intestinal ultrasound scoring in clinical trials for luminal Crohns disease

Besides the results from preclinical models of breast cancer shows that blocking the cancer's ability to use glutathione slowed down tumor growth Further making use of an advanced technology to search for therapies that could inhibit a tumor's ability to use glutathione, the team identified pharmacological targeting of the activity of -glutamyltransferases (GGT) using GGsTop, a putative inhibitor of GGT activity prevents the breakdown of circulating GSH leading to reduced tumour cysteine levels and slowed tumour growth In a nutshell, the findings indicate a non-canonical role for GSH in supporting tumours by acting as a reservoir of amino acids and that depriving tumours of extracellular GSH or inhibiting its breakdown could potentially prove to be a therapeutically tractable approach for patients with cancer Hecht, F., Zocchi, M., Tuttle, E.T

GeorgiouSiafis SK, Tsiftsoglou AS (2023) The key role of GSH in keeping the redox balance in mammalian cells: mechanisms and significance of GSH in detoxification via formation of conjugates