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Iron metabolism markers include ferritin (FTL and FTH1), transferrin (TF) and transferrin receptor 1 (TFR1), and the intracellular free iron pool (LIP) [68, 69]

These factors together contribute to the ICU microbiome crisis (17)

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Disruption of any part of these endogenous antioxidant regulatory systems is sufficient to trigger ferroptosis ( Oxidation in ferroptosis can occur via both iron-based auto-oxidation or enzymatic-mediated mechanisms ( 2+ ) iron reacts directly with oxygen leading to the formation of ferric (Fe 3+ ) iron and a radical (Yuan et al., 2016) and inhibition of iron sulfur cluster biogenesis have been shown to increase ferroptosis sensitivity in cancer cells (Wang et al., 2016