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This epigenetic intervention engages in extensive cross-talk, potentially through global demethylation and modulation of microRNA expression, thereby reversing aberrant gene transcription profiles in cancer (65)

Common cycling patterns include standard cycles of 8 weeks on followed by 4 weeks off, extended cycles of 12 weeks on followed by 6 weeks off for more aggressive protocols, and conservative cycles of 6 weeks on followed by 3 weeks off for those preferring a cautious approach

Lifestyle factors include a bad diet full of processed fats, heavy alcohol consumption, obesity, mental stress, and sleep deprivation

In general, apoptosis of granulosa cells reduces the availability of hormones and survival factors that are essential for oocytes growth and maturation, impairing oocytes meiotic and developmental competence