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Studies have suggested that Nrf2 is activated in the joints of arthritic mice and patients with rheumatoid arthritis, whereas Nrf2 deficiency is associated with accelerated arthritis development 44,45 , suggesting that Nrf2 might be a potential therapeutic target for OA

3.2 Sulforaphanes role in mitigating neuroinflammation Neuroinflammation is defined as an immune response within the central nervous system (CNS), characterized by the activation of microglia and astrocytes, increased pro-inflammatory cytokines, and potential disruption of neuronal homeostasis (DiSabato et al., 2016)

PMID: 20536470