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The losartan-dependant reduction in the TPR-response to tyramine, which was observed in WKY only, was further enhanced by AdrX ( P 0.014), and a reduced TPR was seen also in AdrX + losartan-pre-treated SHR (Figure 4A)

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A few sporadic observations also suggest that L-carnitine may be useful in patients with coma or in preventing hepatic dysfunction after acute VPA overdose.[19,20] Thus carnitine supplementation in high-risk patients, especially in pediatrics or in acute overdose phase during VPA therapy are now recommended by some scientific committees and textbooks;[21] however, few articles have been published on the efficacy of levocarnitine supplementation in chronic VPA-treated psychiatric patients