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Identification of the retinoic acid-inducible Gprc5a as a new lung tumor suppressor gene

Both COPD and lung cancer show a separation in the time between the exposure and actual disease symptoms, which for COPD can be 30 years or more

7 Other cell-derived exosomes: synergistic pathogenicity and repair mechanisms in multidimensional networks In the complex pathological microenvironment of sepsis-associated ARDS, in addition to the core axis composed of alveolar epithelium, endothelium, and macrophages, exosomes derived from neutrophils, platelets, and mesenchymal stem cells play equally crucial roles

Future investigations utilizing targeted mechanistic interventions and causal experimental approaches (e.g., specific pathway inhibitors or genetic models) are warranted to clarify direct cause-and-effect relationships