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Additionally, we estimated an ongoing annual burden of 46 hours per hospital with a cost of $3,610.88 per hospital, resulting in a total national burden of 276,092 hours (46 hours 6,002 hospitals) and total cost of $21,672,502 ($3,610.88 6,002 hospitals), to make required annual updates to the hospitals' standard charge information

Across the entire rare disease trial continuum, DHTs hold promise to support patient-centric approachesfrom trial design to patient recruitment and retention, and to data monitoring, outcome assessment, and long-term healthcare (Fig

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