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aeruginosa secretes TesG via the TesABC Type I secretion system, which impairs alveolar macrophage activity by inhibiting RhoA-mediated immune signaling, thereby promoting biofilm formation and infection chronicity (Fig

The cofactors FAD and FMN, which include vitamin B2, are transferred to an electron by the enzyme methionine synthase reductase (MTRR) during the subsequent reactivation cycle