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Intriguingly, reduction of fasting plasma BCAAs levels alone is insufficient to improve insulin sensitivity, suggesting a potentially synergistic role of multiple tissues in modulating BCAAs metabolism to alter insulin responsiveness ( 3 Metabolic dysregulation: molecular bridges between DM and pulmonary injury DM creates a pathological environment for multi-organ injury through comprehensive dysregulation of carbohydrate, lipid, and amino acid metabolism

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Int J Biochem Cell Biol 110:111121