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27 Studies measuring biomarkers of the dangerous substances in tobacco smoke (see Section 12.5.6) find that, compared to quitting completely, smokers who cut down still have relatively high levels of biomarkers of oxidative stress (an imbalance of free radicals and antioxidants in the body) such as glutathione 28 and other metabolites such as thiocyanate, 29 TNE-2, NNAL, NNN, 2-Fluorene, HPMA, CYMA, and MHB3

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Compared with an earlier cohort of 220,000 men in China, the proportion of smokers who had quit rose from 3% in 1991 to 9% in 2006 in CKB ( IJE 2011