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After oral administration, collagen-based supplements transit across the intestinal epithelium via transcellular and paracellular transport, followed by secretion into the lymphatic system or bloodstream of a substantially non-degraded therapeutic, requiring the circumvention of multiple structural and functional barriers (Fig

PLP, pyridoxal phosphate

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Thioctic acid has been shown to be effective in a wide range of clinical conditions including diabetes and its complications, heart diseases, cancer, heavy metal intoxication, HIV infection, cataract, liver diseases, neurodegenerative diseases and age-related pathologies [39]