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Vitamin B12 in Foods, Food Supplements, and Medicines-A Review of Its Role and Properties with a Focus on Its Stability

While research shows some benefits (for example improved sleep efficiency, reduced sleep latency) in controlled settings, there are still questions around long-term safety, especially in healthy subjects or non-clinical contexts

With regular assessment of hematological indices and urinary protein levels as the key monitoring parameter, some protocols recommended periodic measurements of serum B12 to adjust dosing as needed to prevent B12 overdosage which can lead to unnecessarily high serum levels and potential adverse effects such as acneiform eruptions, rash, or gastrointestinal discomfort [42, 43]

E., Yodh, A