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Moreover, high humidity levels, typically exceeding 70%, play a crucial role in sustaining the vigor of cocoa trees, ensuring the health and vitality of their leaves and fruit (Delgado-Ospina, Molina-Hernndez, Chaves-Lpez, Romanazzi, & Paparella, 2021)

Importantly, these effects could be recapitulated in cysteine desulfurase (NFS1) knockdown cells with impaired iron-sulfur cluster synthesis, indicating that phenotypes observed in SLC25A39/40 knockout cells are likely a consequence of an iron-sulfur cluster deficiency (Extended Data Fig