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10.1016/j.cell.2022.05.008 73 HamlbarE

This was manifested in Miln + XAV939 rats as a significant 38.6% decrement in 5-HT level compared to their XAV939-free counterparts

3.2.2 Neurodegenerative disorder Gut microbiota dysbiosis cause high permeability of the intestine and BBB through the gut-brain axis by increasing LPS, T helper cells, pro inflammatory cytokines