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doi: 10.3389/fphar.2025.1586345 Received 02 March 2025 Accepted 15 May 2025 Published 29 May 2025 Volume 16 - 2025 Edited by Huazheng Liang, Monash University - Southeast University Joint Research Institute (Suzhou), China Reviewed by Ayesha Wadood, Nuclear Institute for Agriculture and Biology, Pakistan Alexandra Daniela Rotaru-Zavaleanu, University of Medicine and Pharmacy of Craiova, Romania Albeiro Marrugo Padilla, University of Cartagena, Colombia Updates Copyright 2025 Zheng, Tan, Wang, Mao and Guo

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Further studies would be needed to determine if Box1Box2 sequences can have relevant interactions with two JAKs simultaneously, although it was suggested that this may have been due to a crystal artifact (73)