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Thus, our data suggest that lipid aldehyde defence mechanisms are impaired in the diabetic retina and that this may represent a major mechanism through which toxic aldehydes and ALEs accumulate in this tissue during DR

Moreover, grafting fetal astrocytes bearing SOD1G93A to the spinal cord of healthy mice precipitated ALS-like pathology 244 , while transplanting healthy astrocytes slowed ALS progression in rats carrying mutant SOD1 G93A (ref

The amount varies widely by peptide