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Mitochondrial dysfunction could not be compensated by increasing oxidative phosphorylation, so that it was only compensated by activating the glycolytic pathway, which was inefficient at producing ATP (18)

J Clin Endocrinol Metab 77:13841387

10.1016/j.pestbp.2024.105988 153 SuzawaM.IngrahamH

These limitations dont invalidate the positive safety findings but do suggest that comprehensive medical supervision remains appropriate for anyone using AOD-9604, particularly for off-label applications or extended treatment periods