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You may only need one dose of some iron infusions

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Following gut immune activation, activated immune cells and effector molecules such as cytokines [e.g., Interleukin-17 (IL-17), Tumor Necrosis Factor-alpha (TNF- )] can promote local inflammatory responses, alter the oral microecological environment, and either inhibit or promote the growth of specific microbial communities, playing a pivotal role in the regulation of oral microbiota (Nagao et al., 2022)

On the other hand, classical methods that detect the changes of properties for the overall system cannot provide accurate information on what occurred among individual components in the complex system