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However, PPAR is the main regulator of lipid homeostasis in the liver and was proposed as the sexually dimorphic target in MASLD

Copper serves as an essential cofactor for enzymes including lysyl oxidase (critical for collagen cross-linking), superoxide dismutase (SOD1, a key component of antioxidant defense), and cytochrome c oxidase (essential for cellular respiration) (Pickart & Margolina, 2018)

doi: 10.1038/s41591-018-0336-8 283 YinY

However, there is increasing experimental and clinical evidence for interactions between abnormal DA metabolism and mitochondrial defects in schizophrenia, which has more complex and diverse clinical manifestations in categories of positive symptoms, negative symptoms, and cognitive impairment