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First-in-human, phase i dose-escalation and dose-expansion study of trophoblast cell-surface antigen 2-directed antibody-drug conjugate datopotamab deruxtecan in non-small-cell lung cancer: TROPION-PanTumor01

These mechanisms include enhanced metabolic activity of drug-detoxifying proteins such as glutathione-S-transferase, increased efflux of the drug partially caused by upregulation of ATP-binding cassette (ABC) transporters, changes in microtubule formation and kinetics due to overexpression of III-tubulin, and mutations in tumor suppressor genes [101]

Perhaps the mechanism that sigma1 receptor agonists can prevent virus replication might also work, but the group who used a sigma1 receptor antagonist was too small to compare it with the big group who used an sigma1 agonist and we got only anecdotal evidence for it

(PubMed) Lefer DJ