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Only two residues that interact ionically with NADP(H) in the bovine catalase (Asp212 and His304) differ in HPII (Glu270 and Glu362), but it has been proven that their mutation to the bovine sequence does not promote nucleotide binding [4]

Hyperpigmentation of the facial skin sometimes occurs during pregnancy, a condition known as melasma, aka the mask of pregnancy. Melasma appears more often in darker-skinned women, and can appear in dark-skinned men as well, although over 90% of those affected are women

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