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Toxic metals and poor cellular energy may worsen the bottleneck, allowing adenosine and SAH to build up and methylation to slow

5i, j, cell migration was elevated in all treatment groups relative to the control

Of the total adverse events reported, 37% were gastrointestinal in nature [207 events in 73 (77%) of 95 participants], most frequently nausea [67 events in 53 (56%) participants], vomiting [43 events in 23 (24%) participants], and dyspepsia [32 events in 27 (28%) participants]

Systemically, because it involves copper, there is a theoretical risk of copper overload with prolonged, high-dose use without proper cycling