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60 Senescence Senescence is the permanent arrest of the cell cycle, and it is well accepted as one of the major barriers to inhibiting tumorigenesis

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Spatial heterogeneity was assessed by 1) the variability of LS calculated as the difference between the maximum and minimum LS divided by the maximum LS and 2) the coefficient of variation (CoV) calculated as the standard deviation of LS at each MRE slice divided by the respective mean LS

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In conclusion, we have provided a comprehensive overview of the widespread epigenetic dysregulation in cancer and its association with therapeutic resistance in this review