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It has been shown that p53 decreases cystine uptake and intracellular GSH and induces ferroptosis by transcriptionally suppressing the expression of SLC7A11 (Ou et al., 2016)

The weighted difference for each treatment was then computed by multiplying the median difference by its corresponding weight and sum of these weights was treated as total weighted difference across treatment conditions

Therefore, antioxidant therapies aimed at reducing oxidative stress represent a promising approach for protecting the BBB and mitigating cognitive decline (Rochfort et al., 2014)

Chronic treatment with beta-blockers lowers arterial pressure more than acute treatment, possibly because of reduced release of renin by the kidneys (the release of which is partly regulated by 1 -adrenoceptors in the kidney)