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Because Syn is a substrate of cathepsin D, and also, in its aggregated form, a principal pathological feature of PD 27 , we next investigated whether low-dose CO might affect the levels of Syn directly, and the levels of Syn phosphorylated on Serine 129 (Syn pSer129 ), a form of the protein associated with aggregates in PD patients, and also a pathological feature of PD-associated Syn A53T neurotoxicity in our rodent model 28

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Whilst smoking is not traditionally considered a primary cause of fatty liver disease in the same way that alcohol consumption or obesity are, emerging evidence suggests that tobacco use is associated with both the development and progression of hepatic steatosis