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Apart from bacterial translocation due to a leaky gut, new research has shown that microbiota in the dental-brain axis, uterus-brain axis, and skin-brain axis may be involved in MDD [128, 197, 198]

The RDA is around 320420mg/day depending on age and sex

Studies on the changes of pharmacokinetics behaviors of phytochemicals and the influence on endogenous metabolites after the combination of Radix Bupleuri and Radix Paeoniae Alba based on multi-component pharmacokinetics and metabolomics