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Initial UPR is aimed at coping with the stress, whereas excessive stress triggers cell death

It has the functions of protecting liver, benefiting gallbladder, reducing blood pressure, sedation, hemostasis and detumescence ( via alleviating the hypothalamic-pituitary-adrenal (HPA) axis dysfunctions ( Recent evidence suggests that oxidative stress processes might play a relevant role in the pathogenesis of many major psychiatric disorders, including depression

To understand what causes Long COVID, we must examine the profound impact of the initial SARS-CoV-2 infection on the body's antioxidant reserves

Mahmoud et al., 2019)