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27 Plasma samples were collected at baseline and two-time points: 60 days after starting sorafenib therapy (orally administrated at 400 mg twice daily) or upon the progression of disease (PD)

Ideally, tumour-derived Wnt5 signaling induces activates -catenin in tumour-associated DCs (TADC), causing secretion of indoleamine 2,3-dioxygenase (IDO), which promotes the generation of Treg cells to suppress anti-tumour T cell activity ( via the transcription factor Foxp3, improve oxidative phosphorylation and increase the NAD: NADH ratio to survive in a low glucose and high lactic acid environment (specifically the PC microenvironment)

Gbolahan Oduselu was supported by a WACCBIP-DELTAS II Postdoctoral fellowship (DEL-22-014: Awandare)

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