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Added to it, components like matrix metalloproteinases (MMPs), ECM integrin, ECM proteins, and enzymes have also been shown to influence the course of the breast cancer cycle and associated reduction in sensitivity to conventional chemotherapeutic treatment [73,74,75,76]

These enzymes are responsible for the metabolism of B(a)P to a carcinogenic compound BPDE [benzo(a)pyrene-7,8-diol-9,10-epoxide], and CYP induction is associated with damage to the DNA of spermatozoa and ROS overexpression ( Overall, the results presented here show how the use of Modified Risk Tobacco Products can induce some of the same toxicological outcomes triggered by tobacco smoking, although less marked

During the proliferative phase, TGF- recruits fibroblasts, keratinocytes, and endothelial cells, stimulating collagen and ECM deposition, as well as angiogenesis via increased VEGF expression [70]

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