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The test compound was pre-incubated with purified human recombinant 12-LOX or 15-LOX for 1 min

In previous neuroimaging studies, concentrations of these amino acids (in addition to the density and activity of neurotransmitter receptors and transporters) have been associated with mood disorders and memory dysfunction (Vaiva et al., 2004), suggesting that the GABAergic system is involved in the pathophysiology of PTSD

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10.1053/j.gastro.2021.08.003 Gastroenterology 28 CattaneoA.CattaneN.GalluzziS.ProvasiS.LopizzoN.FestariC.et al (2017)