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While Huntingtons disease is widely considered to be due to a gain-of-function toxic effect, it has been demonstrated through selective deletion of Htt in striatal projection neurons of mice that these neurons require Htt for motor regulation, synaptic development, cell health, and survival during aging ( Free copper enhances the aggregational toxicity of Htt (Lobato et al., 2024)

[DOI] [PMC free article] [PubMed] [Google Scholar] Iadecola C, Anrather J

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Among the five major epithelioid OC tissue types recognized by the World Health Organization criteria in 2014, high-grade serous OC (HGSOC) is the most common histological subtype in the clinic, accounting for 70-80% of OC deaths (8)