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GHK-Cu (glycyl-L-histidyl-L-lysine copper) is a naturally occurring tripeptide-copper complex first identified in human blood plasma

In COPD studies, GHK-Cu at 10 nanomolar concentration restored lung fibroblasts ability to contract and restructure collagen, a function that is severely compromised in COPD patients

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The restraints were derived from (i) NOE restraints from intermolecular and intramolecular cross-peaks in NOESY spectra (described in NMR spectroscopy section), (ii) TALOS derived p53 TAD2 and FOXO4-DRI backbone dihedral angles, (iii) hydrogen bond restraints (regions p53 residues 4752, FOXO4-DRI residues 918